Ultrashort Bradycardic Effect of Newly Synthetized Compounds

• Authors: BARTOŠOVÁ Ladislava; FRYDRYCH Marek; VACULOVÁ G.; BERÁNKOVÁ K.; BÉBAROVÁ Markéta; OPATŘILOVÁ R.; STRNADOVÁ V.; MOKRÝ P.; BRUNCLÍK V.; KOLEVSKÁ J.; KRČMÁŘ J.; BARTOŠÍKOVÁ L.; FLORIAN T.; NEČAS J.
• Year of publication: 2006
• Type: Article in Periodical
• Magazine / Source: Acta Veterinaria Brunensis
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: bradycardic effect;membrane currents;esmolol;rat;heart rate
• Description: Changes in heart rate induced by four different doses of two newly synthetized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. Their effects were compared with esmolol. Both compounds demonstrated significant bradycardic effects and induced blockade of the fast sodium current (INa) and potassium currents (Ito, IK1, IK).