Publication details
Analysis of metallothionein content in blood and tumor in patients with head and neck cancer
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | 6th Joint Workshop of Middle-German and Czech ENT specialists |
| MU Faculty or unit | |
| Citation | |
| Keywords | metallothionein, head and neck cancer, tumor marker |
| Description | Metallothionein (MT) is an intracellular, low-molecular, cystein rich protein. MT is involved in zinc homeostasis, heavy metals metabolism and protection against oxidative stress. Recent studies have reported on the possible role of MT in carcinogenesis. MT overexpression was imunohistochemically confirmed in many different types of tumors. In most cases the high MT level was associated with worse prognosis and aggressive behavior of malignancy. Our study was aimed at MT concentration in full blood, tumor tissue and intact mucosa in patients with histologically verified head and neck tumors. MT level was measured by adsorptive transfer stripping technique (AdTS) with differential pulse voltametry (DPV) in blood and homogenized tumor tissue. Recieved results were correlated with clinical and pathological tumor characteristics (histology, staging, grading). |