Publication details
Vliv metanandamidu na aktivitu jaterních izoenzymů CYP1A2 a 2C6 v preklinickém experimentu
| Title in English | The influence of methanandamide on the activity of hepatic isoenzymes CYP1A2 and 2C6 in preclinical trial |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | cytochrome P450; methanandamide; isolated perfused rat liver |
| Description | Experiments on the activity of substances from Cannabis led to discovery of endocannabinoid regulation system. Many ligands of cannabinoid receptors are known nawadays. These ligands acts as agonistically or antagonize the effects of endogenous cannabinoids on CB receptors. The group of endogenous ligands is represented by anandamide - agonist of CB1 and CB2 receptors. Methanandamide is synthetic analogue of anandamide, which is metabollicaly more stable and more selective for CB1 receptors than anandamide. It's worth to determine effects, which are not necessarilly connected to receptor activity of CB ligands. It's necessary to estabilish the interactional potential caused by changes in cytochrome P450 activity due to the probable clinical usage of cannabinoids. The aim of our work was to estabilsh the influence of methanandamide on the activity of hepatic isoenzymes CYP2C6 and 1A2 on the model of isolated perfused rat liver. We demonstrated the induction of CYP2C6 activity in rat after 7 day administration of metahnandamide at the dose of 1mg/kg/day. The activity of CYP1A2 was practically unchanged. |
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