Publication details
Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease.
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Movement Disorders |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | overt reading; paralinguistic aspects of speech; Parkinson's disease; functional magnetic resonance imaging |
| Description | Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the BOLD response to overt sentence reading in: 9 treated female patients with mild to moderate PD and 8 age-matched healthy female controls. Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects of speech production. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. |
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