The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.
|Year of publication||2008|
|Type||Article in Periodical|
|Magazine / Source||: Molecular Biology of the Cell|
|MU Faculty or unit|
|Field||Genetics and molecular biology|
|Keywords||non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus|
|Description||Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.|