Safe allogeneic hematopoietic stem cell transplantation for renal cell carcinoma: Novel approach using selective depletion of alloreactive donor T cells.

• Authors: HANÁK Libor; MICHÁLEK Jaroslav; MATĚJKOVÁ Eva; LAUEROVÁ Ludmila; FOLTÁNKOVÁ Veronika; VITETTA Ellen
• Year of publication: 2008
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: It is possible to selectively deplete donor alloreactive T-cells with anti-CD25 IT minimizing or eliminating the risk of GVH disease. This strategy eliminates alloreactivity and preserves GVT reactivity in patients with renal cell carcinoma. Thus the allogeneic hematopoietic stem cell transplantation using selectively allodepleted donor T cells seems to be a valuable alternative to recent treatment strategies.

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