Publication details
Complex assessment of endocrine disruptive activity in the river ecosystem using active and passive sampling and bioassays
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Proceedings |
| Conference | Abstract Book - SETAC Europe 18th Annual Meeting |
| MU Faculty or unit | |
| Citation | |
| Field | Water pollution and control |
| Keywords | (anti)androgenicity; (anti)estrogenicity; in vitro bioassays; passive sampling |
| Description | The aim of this study is the interconnecting of chemical and biological monitoring to obtain complex characterization of contamination in the aquatic environment, focused especially on endocrine disruptive (ED) activity. The study has been conducted in a region of city agglomeration in Central Europe with 400,000 inhabitants and many industrial activities. Multiple types of integrative passive samplers have been used to detect presence of contaminants with ED-potential in water - SPMD (Semi-Permeable Membrane Devices) and POCIS (Polar Organic Chemical Integrative Sampler) for polar pesticides and pharmaceuticals. Battery of in vitro bioassays has been used to assess contamination by compounds with specific modes of action in water, sediments and fish tissue extracts. The bioassays with recombinant yeast and cell systems have been used to evaluate cytotoxic, dioxin-like, (anti)estrogenic and (anti)androgenic potency. The complex approach enabled to assess the presence and distribution of compounds with specific mode of action in various components of the river ecosystem as well as elucidate the character ED-active compounds in the river water. The project has been supported by MSMT 2B06093 and INCHEMBIOL 0021622412. |
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