Publication details

Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

Authors

MIKULKOVÁ Zuzana PRAKSOVÁ Petra ŠTOURAČ Pavel BEDNAŘÍK Josef ŠTRAJTOVÁ Lucie PACASOVÁ Rita BĚLOBRÁDKOVÁ Jana DÍTĚ Petr MICHÁLEK Jaroslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Cellular Immunology
MU Faculty or unit

Faculty of Medicine

Citation
Field Immunology
Keywords Type 1 diabetes mellitus; Multiple sclerosis; Autoimmune diseases; Regulatory T-cells; Suppressor cells
Description Type 1 diabetes mellitus and multiple sclerosis are organ-specific autoimmune diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic beta-cells and central nervous system, respectively. Using four-colour flow cytometry, T-lymphocyte populations having an important function in autoimmune processes were analyzed. The observed data demonstrate significant differences among patients with T1D and MS in comparison to healthy individuals.
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