Publication details

Ovlivnění buněčných linií A2780 a A2780cis v závislosti na aplikaci ultrazvukového pole a cytostatika

Title in English Effect of cell line A2780 and A2780cis depending on the application of ultrasonic fields and cytostatics
Authors

BERNARD Vladan ŠKORPÍKOVÁ Jiřina MORNSTEIN Vojtěch

Year of publication 2010
Type Article in Periodical
Magazine / Source Folia Medica Cassoviensia
MU Faculty or unit

Faculty of Medicine

Citation
Field Biophysics
Keywords cisplatin; ovarian cells; viability
Description The study aims to publish partly results of the in vitro experiments of low-power ultrasound, the anti-cancer drug cisplatin, and their combined application. The effects of the viability changes were studied in two lines of human ovarian carcinoma cells, A2780 and cisplatin resistant A2780cis. Experimental groups were used: exposure to ultrasonic field, application of cisplatin, exposure to ultrasound followed by cisplatin, and presence of ciplatin followed by exposure to application ultrasound. Ultrasound far field was used at intensities of 1.5 W/cm2 for 10 min exposure; cisplatin was applied at concentrations of IC50. The results suggestive to that a combined effect of ultrasound and cisplatin was more effective than that of ultrasound or cisplatin alone.

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