Publication details
Molekulární prediktory u nádorů hlavy a krku
| Title in English | Molecular Predictors in Head and Neck Tumours |
|---|---|
| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | Head and neck cancer-biological markers-prognosis-targeted therapy |
| Description | This reviw summarizes biological markers of head and neck cancer, which havje emerged from recent developments in molecular changes during carcinogenesis. These markers could be evaluated in every step that is believed to be necessary for the development of a cancer: acquisition of autonomous proliferative signaling (EGFR), proliferative activity of tumor cells (DNA content, Ki-67, mitotic index), inhibition of growth inhibitory signals (Bcl-2), apoptosis (p53), immortalization (telomerase), angiogenesis (CD34, VEGF) and metastasis (MMP-9, E-cadherin, I-CAM aj.). Most of these biological markers are in the stage of preclinical research. Significant progress was reached in application of targeted therapy in head and neck cancer. |