Publication details

Molekulární prediktory u nádorů hlavy a krku

Title in English Molecular Predictors in Head and Neck Tumours


Year of publication 2010
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Field ORL, ophthalmology, stomatology
Keywords Head and neck cancer-biological markers-prognosis-targeted therapy
Description This reviw summarizes biological markers of head and neck cancer, which havje emerged from recent developments in molecular changes during carcinogenesis. These markers could be evaluated in every step that is believed to be necessary for the development of a cancer: acquisition of autonomous proliferative signaling (EGFR), proliferative activity of tumor cells (DNA content, Ki-67, mitotic index), inhibition of growth inhibitory signals (Bcl-2), apoptosis (p53), immortalization (telomerase), angiogenesis (CD34, VEGF) and metastasis (MMP-9, E-cadherin, I-CAM aj.). Most of these biological markers are in the stage of preclinical research. Significant progress was reached in application of targeted therapy in head and neck cancer.

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