Publication details

Importance of screening of IgG anti-IgA antibodies in hypogammaglobulinemic subjects to prevent anaphylactoid reactions


THON Vojtěch

Year of publication 2010
Type Article in Periodical
Magazine / Source Klinická imunológia a alergológia
MU Faculty or unit

Faculty of Medicine

Field Immunology
Keywords anti-IgA antibodies; anaphylactoid reaction; hypogammaglobulinemia
Description Anti-IgA antibodies can cause severe anaphylactoid reactions in the case of blood transfusion or substitution immunoglobulin therapy in patients with hypogammaglobulinemia. We found a significant amount of anti-IgA antibodies in 10 % of patients with the most common primary hypogammaglobulinemia (selective IgA deficiency and common variable immunodeficiencies) where the serum IgA level was lower than 0.05 g/L. Knowledge of the presence of antibodies against IgA is important in clinical practice in order to prevent an anaphylactic reaction during blood transfusion or during immunoglobulin substitution therapy.
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