RNDr. Pavel Krejčí, Ph.D.

2011

• The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting insuppression of human myeloma cell growth and survival.

  SCUTO A. KREJČÍ Pavel POPPLEWELL L. WU J. WANG Y. KUJAWSKI M. KOWOLIK C. XIN H. CHEN L. WANG Y. KRETZNER L. YU H. WILCOX W.R. YEN Y. FORMAN S. JOVE R.

  Article in Periodical

  Leukemia, year: 2011, volume: 25, edition: 3, DOI

• Wnt/PCP pathway regulates B-cell migration in chronic lymphocytic leukemia

  KAUCKÁ Markéta VERNER Jan PROCHÁZKOVÁ Jiřina PLEVOVÁ Karla STEHLÍKOVÁ Olga KREJČÍ Pavel KOZUBÍK Alois MAYER Jiří POSPÍŠILOVÁ Šárka BRYJA Vítězslav

  Conference abstract

  Year: 2011, type: Conference abstract

2010

• Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

  FOLDYNOVÁ-TRANTÍRKOVÁ S. SEKYROVÁ P. TMEJOVÁ Kateřina BRUMOVSKÁ E. BERNATÍK Ondřej BLANKENFELDT W. KREJČÍ Pavel KOZUBÍK Alois DOLEZAL T. TRANTÍREK Lukáš BRYJA Vítězslav

  Article in Periodical

  Breast Cancer Research, year: 2010, volume: 2010, edition: 12/3, DOI

• FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

  KREJČÍ Pavel PROCHÁZKOVÁ Jiřina SMUTNÝ Jiří CHLEBOVÁ Katarína LIN Patricia AKLIAN Anie BRYJA Vítězslav KOZUBÍK Alois WILCOX William R.

  Article in Periodical

  Bone, year: 2010, volume: neuveden, edition: 47

• Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

  WITTE Florian BERNATÍK Ondřej KIRCHNER Katharina MAŠEK Jan MAHL Annika KREJČÍ Pavel MUNDLOS Stefan SCHAMBONY Alexandra BRYJA Vítězslav STRICKER Sigmar

  Article in Periodical

  FASEB JOURNAL, year: 2010, volume: 24, edition: 7, DOI

• Nf449 is a novel inhibitor of fibroblast growth factor receptor 3 (fgfr3) signaling active in chondrocytes and multiple myeloma cells

  KREJČÍ Pavel MURAKAMI Shunichi PROCHÁZKOVÁ Jiřina TRANTÍREK Lukáš CHLEBOVÁ Katarína OUYANG Zhufeng AKLIAN Anie SMUTNÝ Jiří BRYJA Vítězslav KOZUBÍK Alois WILCOX Wiliam R.

  Article in Periodical

  J. Biol. Chem., year: 2010, volume: 285, edition: 27, DOI

2009

• FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

  MATSUSHITA Takehiko WILCOX William YUK YU Chan KAWANAMI Aya BÜKÜLMEZ Hülya BALMES Gener KREJČÍ Pavel MEKIKIAN Pertchoui B OTANI Kazuyuki YAMAURA Isakichi WARMAN Matthew L. GIVOL David MURAKAMI Shunichi

  Article in Periodical

  Human Molecular Genetics, year: 2009, volume: 18, edition: 2

• Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

  KREJČÍ Pavel PROCHÁZKOVÁ Jiřina BRYJA Vítězslav JELÍNKOVÁ Petra PEJCHALOVÁ Kateřina KOZUBÍK Alois TOMPSON Leslie Michels WILCOX William R.

  Article in Periodical

  Cellular Signalling, year: 2009, volume: 21, edition: 1, DOI

• High molecular weight FGF2: the biology of a nuclear growth factor

  CHLEBOVÁ Katarína BRYJA Vítězslav DVOŘÁK Petr KOZUBÍK Alois WILCOX W.R. KREJČÍ Pavel

  Article in Periodical

  Cellular and molecular life sciences : CMLS, year: 2009, volume: 66, edition: 2, DOI

• Molecular pathology of the fibroblast growth factor family.

  KREJČÍ Pavel PROCHÁZKOVÁ Jiřina BRYJA Vítězslav KOZUBÍK Alois WILCOX William

  Article in Periodical

  Human Mutation, year: 2009, volume: 30, edition: 9, DOI