RNDr. Pavel Krejčí, Ph.D.

2026

• Engineered fibroblast growth factor 1 variants uncouple glucose-lowering effects from mitogenic activity with therapeutic potential for type 2 diabetes

  CZYREK Aleksandra Anna KROWARSCH Daniel SIDOR Szymon JANISZEWSKI Michal DRZAZGA-WILK Ewa BAZYDLO-GUZENDA Katarzyna BUDA Pawel PIECZYKOLAN Jerzy POREBSKA Natalia MINKIEWICZ Marta KREJČÍ Pavel WIECZOREK Maciej OTLEWSKI Jacek ZAKRZEWSKA Malgorzata

  Article in Periodical

  MOLECULAR BIOMEDICINE, year: 2026, volume: 7, edition: 1, DOI

• Infigratinib is a weak inhibitor of the FGFR3-N540K mutant associated with hypochondroplasia

  URSACHI Vlad-Constantin FEKETOVÁ Zuzana CZYREK Aleksandra Anna ŠESTÁKOVÁ Klára SVOZILOVÁ Kateřina RICO LLANOS Gustavo KREJČÍ Pavel

  Article in Periodical

  Journal of bone and mineral research, year: 2026, DOI

2025

• Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors

  BOSÁKOVÁ Michaela POOVAKULATHU ABRAHAM Sara WACHTELL Davis ZIEBA Jennifer T KOT Alexander NITĂ Alexandru CZYREK Aleksandra Anna KOUDELKA Adolf URSACHI Vlad-Constantin FEKETOVÁ Zuzana RICO-LLANOS Gustavo SVOZILOVÁ Kateřina KOCEROVÁ Petra FAFÍLEK Bohumil GREGOR Tomáš KOTAŠKOVÁ Jana DURAN Ivan VAŇHARA Petr DOUBEK Michael MAYER Jiří SOUČEK Karel KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Cell Communication and Signaling, year: 2025, volume: 23, edition: 1, DOI

• FGFR2 residence in primary cilia is necessary for epithelial cell signaling

  NITĂ Alexandru POOVAKULATHU ABRAHAM Sara ELREFAAY Eman FAFÍLEK Bohumil ČÍŽKOVÁ Eliška URSACHI Vlad-Constantin GUDERNOVÁ Iva KOUDELKA Adolf DUDEJA Pooja GREGOR Tomáš FEKETOVÁ Zuzana RICO LLANOS Gustavo Adolfo SVOZILOVÁ Kateřina ÇELIKER Canan CZYREK Aleksandra Anna BÁRTA Tomáš TRANTÍREK Lukáš WIEDLOCHA Antoni KREJČÍ Pavel BOSÁKOVÁ Michaela

  Article in Periodical

  Journal of cell biology, year: 2025, volume: 224, edition: 7, DOI

• Increased thermal stability of FGF10 leads to ectopic signaling during development

  CZYREK Aleksandra Anna BARAN Karolina HRUBÁ Eva HORACKOVA Aneta BOSÁKOVÁ Veronika CHUDZIAN Julia FAFÍLEK Bohumil LASKOVA Veronika STEPANKOVA Veronika BEDNÁŘ David KARL Kelly KASPAREK Petr BOSÁKOVÁ Michaela KILLINGER Michal SZOTKOWSKA Tereza PROCHAZKA Jan ZIEBA Jennifer T RICO LLANOS Gustavo FRIČ Jan HADZIC Stefan LOKU Edma WUJAK Magdalena SVOZILOVÁ Kateřina STROBLOVÁ Michaela SEDLACEK Radislav HRISTOVA Kalina KRAKOW Deborah KUBOVCIAK Jan DELATTRE Mathys BARTOSZEWSKI Rafal BUCHTOVÁ Marcela KROWARSCH Daniel CHALOUPKOVÁ Radka ZAKRZEWSKA Malgorzata KREJČÍ Pavel

  Article in Periodical

  Cellular and molecular life sciences, year: 2025, volume: 82, edition: 1, DOI

• Oral Infigratinib Therapy in Children with Achondroplasia

  RICO LLANOS Gustavo CZYREK Aleksandra Anna KREJČÍ Pavel

  Article in Periodical

  New England journal of medicine, year: 2025, volume: 392, edition: 23, DOI

• POLIPEPTÍDEO TERMOESTÁVEL E MEIO DE CULTURA

  DVOŘÁK Petr KREJČÍ Pavel BÁLEK Lukáš EISELLEOVÁ Lívia KONEČNÁ Žaneta DVOŘÁK Pavel BEDNÁŘ David BREZOVSKÝ Jan ŠEBESTOVÁ Eva CHALOUPKOVÁ Radka ŠTĚPÁNKOVÁ Veronika VAŇÁČEK Pavel PROKOP Zbyněk DAMBORSKÝ Jiří BOSÁKOVÁ Michaela

  Patent

  Publisher: Instituto Nacional da Propriedade Industrial, state: Brazil, patent's number: BR 112018010676-3, year: 2025

• Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

  RYNEŠ Jan IŠTVÁNKOVÁ Eva KRAFČÍKOVÁ Michaela LUCHINAT Enrico BARBIERI Letizia BANCI Lucia KAMARÝTOVÁ Kristýna LOJA Tomáš FAFÍLEK Bohumil RICO LLANOS Gustavo KREJČÍ Pavel MACUREK Libor TRANTÍRKOVÁ Silvie TRANTÍREK Lukáš

  Article in Periodical

  Communications Biology, year: 2025, volume: 8, edition: 1, DOI

• Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer

  ZLÍNSKÁ Vladimíra FEKETOVÁ Zuzana CZYREK Aleksandra Anna CHUDZIAN Julia ZIVKOVIC Martina Lenarcic URSACHI Vlad-Constantin DUDEJA Pooja FAFÍLEK Bohumil RYNEŠ Jan RICO LLANOS Gustavo KOUDELKA Adolf ROY Tanaya BIADUN Martyna RAŠKOVÁ Vendula SVOZILOVÁ Kateřina STROBLOVÁ Michaela KRZYSCIK Mateusz HRISTOVA Kalina KROWARSCH Daniel TRANTÍRKOVÁ Silvie ZAKRZEWSKA Malgorzata TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  MOLECULAR THERAPY-NUCLEIC ACIDS, year: 2025, volume: 36, edition: 1, DOI

2024

• Achondroplasia: aligning mouse model with human clinical studies shows crucial importance of immediate postnatal start of the therapy

  RICO LLANOS Gustavo SPOUTIL Frantisek BLAHOVÁ Eva KOUDELKA Adolf PROCHAZKOVA Michaela CZYREK Aleksandra Anna FAFÍLEK Bohumil PROCHAZKA Jan GONZÁLEZ LÓPEZ Marcos KŘIVÁNEK Jan SEDLACEK Radislav KRAKOW Deborah NONAKA Yosuke NAKAMURA Yoshikazu KREJČÍ Pavel

  Article in Periodical

  Journal of bone and mineral research, year: 2024, volume: 39, edition: 12, DOI