Project information

Molecular pathophysiology of multigene diseases

Project Identification
MSM 141100002
Project Period
1/1999 - 1/2004
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
MU Faculty or unit
Faculty of Medicine
Keywords
Multigenic disease, essential hypertension, ischemia, atopy, diabetes type II, late complications of diabetes, matrix metalloproteinase, gene polymorphism, remodeling, gene derepression, case-control study, PCR, SSCP, RFLP, sequencing.

Effects of allelic variability of the genes coding for matrix metalloproteinases (MMPs) on the etiopathogenesis of the essential hypertension, myocardial ischemia, atopic diseases, and late complications of diabetes II will be studied. Genotyping of individuals will be performed using molecular biological methods, especially PCR, SSCP, RFLP, and/or direct sequencing. Groups of diseased persons will be compared with the appropriate control groups (case-control study).

Publications

Total number of publications: 233


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