Project information

Interdisciplinary approach to study biological systems at the molecular level

Project Identification

LTC17076

Project Period

5/2017 - 3/2020

Investor / Pogramme / Project type

Ministry of Education, Youth and Sports of the CR

INTER-EXCELLENCE
INTER-COST

MU Faculty or unit

Central European Institute of Technology

prof. RNDr. Michaela Wimmerová, Ph.D.

Projekt je zaměřen na integrativní inovační biofyzikální přístupy pro studium proteinů specificky rozpoznávajících sacharidy podílejících se na interakci hostitel-patogen a dále enzymů zapojených do biosyntézy glykokonjugátů. Studované téma je v souladu s akcí COST CA15126 zaměřením na vývoj nových metodologií a technologií, které mají pomoci posunout existující biofyzikální instrumentaci novými nejmodernějšími směry.

Publications

Total number of publications: 9

2020

Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold

SÝKOROVÁ Petra NOVOTNÁ Jitka DEMO Gabriel POMPIDOR Guillaume DUBSKÁ Eva KOMÁREK Jan FUJDIAROVÁ Eva HOUSER Josef HÁRONÍKOVÁ Lucia VARROT Annabelle SHILOVA Nadya IMBERTY Anne BOVIN Nicolai POKORNÁ Martina WIMMEROVÁ Michaela

Article in Periodical

International journal of biological macromolecules, year: 2020, volume: 152, edition: JUN 1 2020, DOI

2019

Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed beta-Propeller Lectin Family

FALTINEK Lukáš FUJDIAROVÁ Eva MELICHER Filip HOUSER Josef KAŠÁKOVÁ Martina KONDAKOV Nikolay KONONOV Leonid PARKAN Kamil VIDAL Sébastien WIMMEROVÁ Michaela

Article in Periodical

Molecules, year: 2019, volume: 24, edition: 24, DOI
Synthesis of beta-D-galactopyranoside-Presenting Glycoclusters, Investigation of Their Interactions with Pseudomonas aeruginosa Lectin A (PA-IL) and Evaluation of Their Anti-Adhesion Potential

MALINOVSKÁ Lenka THAI LE Son HERCZEG Mihály VAŠKOVÁ Michaela HOUSER Josef FUJDIAROVÁ Eva KOMÁREK Jan HODEK Petr BORBÁS Anikó WIMMEROVÁ Michaela CSÁVÁS Magdolna

Article in Periodical

Biomolecules, year: 2019, volume: 9, edition: 11, DOI

2018

AB21, a protein of unknown function from Agaricus bisporus. A case study on utilizing experimental and bioinformatical approaches for functional assignment of unknown proteins

KOMÁREK Jan KAVKOVÁ Eva HOUSER Josef HORÁČKOVÁ Aneta HOLKOVÁ Jitka DEMO Gabriel WIMMEROVÁ Michaela

Conference abstract

Year: 2018, type: Conference abstract
Assessing the Performance of MM/PBSA, MM/GBSA, and QM-MM/GBSA Approaches on Protein/Carbohydrate Complexes: Effect of Implicit Solvent Models, QM Methods, and Entropic Contributions

MISHRA Sushil Kumar KOČA Jaroslav

Article in Periodical

Journal of Physical Chemistry B, year: 2018, volume: 122, edition: 34, DOI
Automated Training of ReaxFF Reactive Force Fields for Energetics of Enzymatic Reactions

TRNKA Tomáš TVAROŠKA Igor KOČA Jaroslav

Article in Periodical

Journal of Chemical Theory and Computation, year: 2018, volume: 14, edition: 1, DOI
How Mycobacterium tuberculosis Galactofuranosyl Transferase2 (GlfT2) Generates Alternating beta-(1-6) and beta-(1-5) Linkages: AQM/MM Molecular Dynamics Study of the Chemical Steps

JANOŠ Pavel KOZMON Stanislav TVAROŠKA Igor KOČA Jaroslav

Article in Periodical

Chemistry - A European Journal, year: 2018, volume: 24, edition: 27, DOI
Structure and properties of AB21, a novel Agaricus bisporus protein with structural relation to bacterial pore-forming toxins

KOMÁREK Jan KAVKOVÁ Eva HOUSER Josef HORÁČKOVÁ Aneta HOLKOVÁ Jitka DEMO Gabriel WIMMEROVÁ Michaela

Article in Periodical

Proteins : structure, function, and genetics, year: 2018, volume: 86, edition: 9, DOI
Synthesis of a-L-fucopyranoside-presenting glycoclusters and investigation of their interaction with recombinant Photorhabdus asymbiotica lectin (PHL)

JANČAŘÍKOVÁ Gita HERCZEG Mihály FUJDIAROVÁ Eva HOUSER Josef KÖVÉR Katalin E. BORBÁS Anikó WIMMEROVÁ Michaela CSÁVÁS Magdolna

Article in Periodical

Chemistry - A European Journal, year: 2018, volume: 24, edition: 16, DOI