Project information
Project information
Od konformace po biologické funkce proteinu HP1
- Project Identification
- GA18-07384S
- Project Period
- 1/2018 - 12/2020
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
Budeme specifikovat funkční vlastnosti HP1 při nero-diferenciaci nebo poškození DNA. Budeme charakterizovat typy HP1 proteinu a jejich domén pomocí FLIM-FRET a hmotnostní spektrometrie (HS). Výsledky HS, týkající se post-translačních modifikacích HP1, použijeme pro predikci HP1 konformace.
Publications
Total number of publications: 6
2021
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Residues flanking the ARK^me3T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations
Biochimica et Biophysica Acta - General Subjects, year: 2021, volume: 1865, edition: 1, DOI
2020
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N-6-Adenosine Methylation in RNA and a Reduced m(3)G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions
Cells, year: 2020, volume: 9, edition: 2, DOI
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The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
International Journal of Molecular Sciences, year: 2020, volume: 21, edition: 21, DOI
2019
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DNA Damage Changes Distribution Pattern and Levels of HP1 Protein Isoforms in the Nucleolus and Increases Phosphorylation of HP1 beta-Ser88
CELLS, year: 2019, volume: 8, edition: 9, DOI
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Role of Fine Structural Dynamics in Recognition of Histone H3 by HP1 gamma(CSD) Dimer and Ability of Force Fields to Describe Their Interaction Network
Journal of Chemical Theory and Computation, year: 2019, volume: 15, edition: 10, DOI
2018
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Irradiation by gamma-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and gamma H2AX
Biochimie, year: 2018, volume: 154, edition: NOV, DOI