Project information
Biologická úloha lektinů v symbióze a patogenezi
- Project Identification
- GA21-29622S
- Project Period
- 1/2021 - 12/2023
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Navrhovaný projekt je zaměřen na studium úlohy lektinů v symbióze a patogenezi v tripartitních systémech, ve kterých se neuplatňuje pouze jednoduchý bivalentní vztah hostitel-patogen. Budeme primárně studovat význam lektinů z klíštěte obecného a lektinů
z bakterií Photorhabdus spp., jež patří mezi lidské i hmyzí patogeny žijící symbióze s hlísticemi Heterorhabditis spp., se snahou pochopit jejich zapojení komplexních patogenních systémech
bakterie-přenašeč-hostitel.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 19
2026
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A glycosaminoglycan-binding LecA-like lectin from Xenorhabdus nematophila: structural and biophysical characterization
CARBOHYDRATE POLYMERS, year: 2026, volume: 388, edition: Sep, DOI
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A newly identified three-domain C-type lectin associated with blood feeding in the tick Ixodes ricinus
TICKS AND TICK-BORNE DISEASES, year: 2026, volume: 17, edition: 5, DOI
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Neutron Crystallography Study of Host-Pathogen Recognition Enhanced by Hydrogen/Deuterium Exchange on Carbohydrates
CHEMISTRYEUROPE, year: 2026, volume: 4, edition: 3, DOI
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Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor-like lectin
THE FEBS JOURNAL, year: 2026, volume: 293, edition: 4, DOI
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Two-domain LecB-like lectin: Unexpected binding properties
Year: 2026, type: Appeared in Conference without Proceedings
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When LecB Is Not Alone: Structural and Functional Analysis of a Two-Domain Lectin
Year: 2026, type: Conference abstract
2025
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Bispecific Thio-linked Disaccharides as Inhibitors of Pseudomonas aeruginosa Lectins LecA (PA-IL) and LecB (PA-IIL): Dual-Targeting Strategy
Chemistry – A European Journal, year: 2025, volume: 31, edition: 5, DOI
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Mysteries of Lectins in Opportunistic Pathogens: Two Domains – One Purpose?
Year: 2025, type: Conference abstract
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The insight into the biology of five homologous lectins produced by the entomopathogenic bacterium and nematode symbiont Photorhabdus laumondii
Glycobiology, year: 2025, volume: 35, edition: 7, DOI
2023
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Dual specificity of PLL2 lectin
Year: 2023, type: Conference abstract