Studying early development of Alzheimer's disease pathology using brain organoids
- Project Identification
- Project Period
- 1/2023 - 12/2023
- Investor / Pogramme / Project type
- MU Faculty or unit
- Faculty of Medicine
Alzheimer's disease (AD) is a neurodegenerative disorder affecting the population worldwide. Currently, iPSCs have been used to create cerebral organoids (COs), which can adequately mimic AD in vitro. These models can also mimic the early development of the brain, and they can thus help to understand the initiation steps and molecular mechanisms of AD. This project aims to uncover mechanisms that lead to the development of AD. We plan to derive COs from fAD iPSCs (and respective non-demented controls) and perform bulk mRNA sequencing of several timepoints during early neural development. Our preliminary data suggest that the early developmental phase and deregulated signaling pathways underlie the development of early-onset familial AD.