Project information

Project information
WNT signaling in mammary fibroblasts

Project Identification
Project Period
1/2023 - 6/2023
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Mammary fibroblasts are major constituents of mammary stroma, which regulate mammary epithelial morphogenesis and homeostasis. Deregulation of mammary fibroblast functions leads to developmental defects and pathologies, including breast cancer. However, regulation of mammary fibroblasts is poorly understood. Our latest, unpublished research uncovered mammary fibroblast heterogeneity and a potential role for WNT signaling in regulation of a critical fibroblast subpopulation, which might form an essential signaling niche of actively growing epithelium in developing mammary gland and be the source of new fibroblasts enwrapping nascent ducts. In this project, we aim to develop a toolkit for research on WNT signaling in mammary fibroblasts in vivo and to obtain strong preliminary data on the role of mammary fibroblasts’ WNT signaling in epithelial morphogenesis with the ultimate goal to build competitive applications to external funding agencies to support our research on this topic.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education

You are running an old browser version. We recommend updating your browser to its latest version.

More info