Project information

Project information
Prioritization of pathways linking aging and Alzheimer’s disease to cognitive decline and dementia (ADPriOMICS)

Project Identification
Project Period
1/2024 - 12/2026
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
The University of Bonn
University Hospital of Köln
University of Luxembourg
University Medical Centers
Institut Pasteur de Lille
Institut Catala de Neurociencies Aplicades (Fundació ACE)

Aging is a major risk factor for cognitive decline and increases the vulnerability of the brain to neurodegenerative diseases, such as Alzheimer’s disease (AD) which, in turn, dramatically accelerates the cognitive deterioration and risk for dementia. The biological pathways linking aging and AD are still poorly understood, partly due to the multitude of alterations induced by both processes. However, identifying biological processes operating at the intersection of aging and AD that convey downstream effects on cognitive decline could enhance our understanding of the aging brain. Furthermore, these processes could provide efficient and effective drug targets since their modulation would simultaneously affect two major determinants of dementia. To identify these processes, ADPriOMICs will combine extensive genome-wide genotype and gene expression data, sequencing information, proteomics, and deep phenotyping in longitudinal cognitive data using an unbiased approach.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education Sustainable Development Goal No.  17 – Partnerships for the goals

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