Project information
Spatiotemporal transcriptome and proteome analysis of Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms (4DPD-Omics)

Project Identification
Project Period
5/2024 - 4/2027
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
MU Faculty or unit
Central European Institute of Technology
Cooperating Organization
University of Debrecen
Lunds Universitet
Royal College of Surgeons in Ireland
University Medical Centers

The overall objective of 4DPD-Omics is to perform a spatiotemporal analysis of gene and protein expression changes to determine whether specific cellular processes implicated in α-Syn pathology act in a cell type- or disease stage-dependent manner, and to identify novel cell-specific targets and strategies for drug development. Through aligned cell-type specific analysis of rodent models and human tissue, we will elucidate common and distinct mechanisms to optimize translation of findings from pre-clinical studies into the clinic. Comparing and interrogating results obtained from in vivo models and human Braak stage 0-VI post mortem tissues will also generate important data for the community regarding the suitability of animal and human post mortem studies for neurodegeneration research.

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