Project information
How the study spatial order of specific genetic loci in nuclei of healthy and malignant tissues can contribute to the diagnostics and treatment of solid tumors.
- Project Identification
- NC5955
- Project Period
- 1/2000 - 1/2002
- Investor / Pogramme / Project type
-
Ministry of Health of the CR
- R&D of Oncology
- MU Faculty or unit
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Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Informatics
- Cooperating Organization
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Institute of Biophysics
- Responsible person Ing. Emilie Lukášová, CSc.
- Responsible person MUDr. Karel Hušek, CSc.
- Responsible person MUDr. Václav Vagunda, Ph.D.
Location of principal genes involved in the development of colorectal carcinoma in cell nuclei of individuals with increased risk of cancer induction will be analyzed by means of confocal fluorescence microscopy in real time.
Publications
Total number of publications: 9
2003
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Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI-1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells
Human Genetics, year: 2003, volume: 112, edition: 2
2002
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3D Structure of the human genome: Order in randomness
Chromosoma, year: 2002, volume: 111, edition: 5
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Optimisation of FISH Methodology for the Study of 3D Structure of Cell Nuclei Using Micro Axial Tomography
Biophysics of the Genome and Its Interactions, year: 2002
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Spatial distribution of centromeric and subtelomeric DNA sequences in interphase nuclei of human Go and stimulated lymphocytes
Biophysics of the genome and its interactions, year: 2002
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Structure of the human genome: Experimental results and models
Biophysics of the genome and its interactions, year: 2002
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The 3D structure of human chromosomes in cell nuclei
Chromosome Research, year: 2002, volume: 10, edition: 7
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Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes
Gene, year: 2002, volume: 292, edition: 1
2001
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Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays
International Journal of Radiation Biology, year: 2001, volume: 77, edition: 4
2000
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Topography of genetic loci in tissue samples: towards new diagnostic tool using interphase FISH and high-resolution image analysis techniques
Analytical Cellular Pathology, year: 2000, volume: 20, edition: 4