Publication details

Analysis of renal stones by capillary isotachophoresis

Authors

JAROLÍMOVÁ Zdeňka LUBAL Přemysl KANICKÝ Viktor

Year of publication 2012
Type Article in Periodical
Magazine / Source Talanta
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.ncbi.nlm.nih.gov/pubmed/22939127
Doi http://dx.doi.org/10.1016/j.talanta.2012.06.039
Field Analytic chemistry
Keywords Capillary isotachophoresis; Urinary calculi (renal stones); Classification; Biomineral analysis; Urine
Description An analytical method for the determination of the composition of renal stones by capillary isotachophoresis with conductometric detection was developed. Using different leading/terminating electrolyte systems, the qualitative and quantitative analysis of organic compounds (urate, xanthate, oxalate) and inorganic ions (phosphate, Ca2+, Mg2+, Na+ NH4+) species commonly present in mixed renal stones in three separate steps can be carried out with limits of detection about 10 mikromol/L. The developed method was validated by the analysis of real samples and can be used for urinary calculi classification. In addition, it was verified that this method can also be employed for the determination of the above mentioned analytes in some other samples (bones, teeth) concerning apatite biominerals (fluoro-, carbonate-, chloro-apatite).
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