Publication details

Vysokodávková léčba a přípravné režimy před transplantací krvetvorných buněk

Title in English High dose treatments and preparatory regimens prior to haematopoietic stem cell transplantation
Authors

TOMIŠKA Miroslav

Year of publication 2012
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords high-dose chemotherapy; hematopoietic stem cell transplantation; conditioning regimen; nonmyeloablative conditioning
Attached files
Description High-dose chemotherapy can be defined as utilization of cytotoxic drug doses that produce bone marrow ablation. Transfusion of autologous graft serves as rescue from otherwise fatal myelotoxicity. Immune reaction of graft versus tumor that lowers relaps rates of malignant disease becomes an important contribution of allogeneic hematopoietic stem cell transplantation. New reduced intensity conditioning regimens with lower initial cytotoxicity rely on this immune effect with the potencial of additional elimination of remaining cancer cells. Decreased toxicity of these regimens enables treatment of patients with comorbidity and/or in higher age.

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