Publication details
Diastolická dysfunkce levé komory ve vyšším věku. Nemoc, nebo fyziologický projev stárnutí?
| Title in English | Diastolic dysfunction in the elderly subjects. Disease or a physiological manifestation of ageing? |
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| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | ageing; echocardiography; diastolic dysfunction; diastolic heart failure |
| Description | Aim: The purpose of this summary paper is to discuss the current knowledge of the impact of age on diastolic function of the left ventricle. Data from the literature: Reports published till this time have convincingly demonstrated a signifi cant relationship of age to diastolic function of the left ventricle. Ageing is a physiological process accompanied by structural changes in both myocardium and arterial bed resulting in worsening of parameters characterizing the left ventricular diastolic function. This „physiological” diastolic dysfunction in the elderly subjects can be explained by the deterioration of passive left ventricular fi lling properties and by worsening of left ventricular relaxation. The detailed analysis of published reports shows problems in distiguishing this „physiological” diastolic dysfunction resulting from physiological tissue ageing from „pathological” diastolic dysfunction refl ecting a disease of cardiovascular system. Conclusion: To interprete correctly values of parameters quantifying diastolic function of the left ventricle, one should take into account the age of subjects under the examination. Further studies are necessary to distinguish exactly „physiological” deterioration of diastolic function associated with ageing from really „pathological” diastolic dysfunction in the elderly subjects. |