Publication details

Výsledek screeningu nutričního rizika u pacientů s karcinomem plic predikuje odpověď nádoru na léčbu

Title in English Results of nutritional risk screening in patients with lung cancer predict tumor response to therapy
Authors

ILLA Petr TOMÍŠKOVÁ Marcela SKŘIČKOVÁ Jana TOMIŠKA Miroslav

Year of publication 2013
Type Article in Periodical
Magazine / Source Studia pneumologica et phthiseologica
MU Faculty or unit

Faculty of Medicine

Citation
Field Pneumology
Keywords lung cancer; NRS; tolerance of treatment; treatment response
Description Background: Malnutrition in cancer patients may be associated with poor tolerance of chemotherapy and lower response rate after oncological treatment. Methods: Nutritional Risk Screening (NRS) 2002 adapted for oncological patients was used to assess the risk of undernutrition in a group of 188 lung cancer patients. The risk was evaluated on a 6-point scale according to common signs of nutritional status and tumor and its treatment risk factors. A score of 3 and more (called "nutritional risk") means a significant risk of malnutrition and poor treatment outcome. Results: There were 133 (70.7 %) men and 55 (29.3 %) women with a mean age of 64.9 years. Tumor stages from I to IV were classified in 10.6 % (I), 4.3 % (II), 9.6 % (IIIA), 25.0 % (IIIB) and 48.6 % (IV] patients. Non-small cell lung cancer was diagnosed in 66.0 % and small cell lung cancer in 27.7 % of patients. Acceptable NRS score of 0-2 points was found in 50.6 %, while in 45.3 % the 3-5 score suggested the risk of malnutrition ("nutritional risk"). Unexpectedly, the toxicity of anticancer treatment was not significantly different between the subgroups ("acceptable score" vs. "nutritional risk") with a mean toxicity on the 0-4 point scale of 1.6 (SD 1-3; 95% CI 1.3-2.0) in patients with higher NRS scores as compared to 1.2 (SD 1.2; 95% CI 1.0-1.5) in the lower NRS score group (p = 0.061). The rate of treatment response (RR) evaluated by imaging techniques was significantly higher in patients with the "acceptable score" (1-2 points) compared to those with a "nutritional risk" (3-5 points) (57 % vs. 30 %; p = 0.001). The overall survival rate was significantly higher in lung cancer patients treated with cytostatics and the "acceptable score" as compared to patients at a "nutritional risk" (13.5 months vs. 7.9 months; p = 0.001). Conclusion: Nutritional risk screening is a significant predictor of tumor response in lung cancer patients. Early detection of malnutrition is important to determine the prognosis of cancer patients as well as to plan effective supportive care.

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