Publication details

Combined effect of silver nanoparticles and therapeutical ultrasound on ovarian carcinoma cells A2780

Authors

BERNARD Vladan MORNSTEIN Vojtěch JAROŠ Josef SEDLÁČKOVÁ Miroslava ŠKORPÍKOVÁ Jiřina

Year of publication 2014
Type Article in Periodical
Magazine / Source Journal of Applied Biomedicine
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.sciencedirect.com/science/article/pii/S1214021X14000283
Doi http://dx.doi.org/10.1016/j.jab.2014.01.002
Field Biophysics
Keywords Nanoparticle; nanosilver; sonodynamic therapy; Ultrasound
Description Antibacterial activity of silver nanoparticles is widely known and used. The effect of application of therapeutical ultrasonic field in the presence of silver nanoparticles <100 nm was examined on human ovarian carcinoma cell A2780. The cell's viability was examined by MTT assay and by life-time microscopy. The presence of nanoparticles in the cell was examined by using electron transmission microscopy. Experimental results indicate a significant decrease of viability of cell, which was affected by the combined action of ultrasound field and silver nanoparticles, compared to the separate exposure of silver nanoparticles or ultrasonic field. The experiments showed a significant effect of succession of application of these two factors. The presence of nanoparticles inside cells after incubation was showed. The results show the possibility of using of ultrasonic field as a factor that can significantly affect cell viability in the presence of silver nanoparticles.
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