Publication details

MALDI-TOF fingerprinting of the whole mammalian cell-lines

Authors

AMATO Filippo KUČERA Lukáš VAŇHARA Petr HAMPL Aleš HAVEL Josef

Year of publication 2014
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Science

Citation
Description Robust cell-lines identification requires reliable databases of cell-lines fingerprints. Mass spectrometric fingerprinting of mammalian cell-lines is a promising way to achieve the goal of fast, cheap, simple and reliable cell-lines authentication. However, general and standardized method for mass spectrometric fingerprinting of the whole mammalian cell-lines is not available to date. We developed, optimized and validated MALDI-TOF mass spectrometric method for reliable, specific and reproducible whole-cell fingerprinting of mammalian cell-lines. Quality and robustness of mass spectrometric fingerprints is demonstrated by statistical analysis of experimental data. Developed method for the whole mammalian cell-lines fingerprinting, in contrast to actual procedures, is inexpensive, fast and it opens the door towards routine cell authentication.
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