Publication details
Pupilární reakce na barevné podněty
| Title in English | Pupillary Response to Chromatic Stimuli |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Česká a Slovenská neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | pupillary reflex; melanopsin; photoreceptor cells |
| Description | Aim of study: To compare chromatic pupillary responses in a group of healthy subjects and to determine if this method can be used for assessing outer and inner retinal function. Material and methods: The study group consisted of 17 healthy subjects. Subjects were tested with a chromatic pupillometer. The parameters of the stimulus were as follows: intensity 28 lx, duration 4 sec, and color blue (420 +/- 20 nm) and red (605 +/- 20 nm). The examined pupil parameters were baseline pupil diameter, maximal constriction time, relative amplitude at maximal constriction, at 3 sec after stimulus onset, at stimulus offset, at 3 sec after stimulus offset and at 7 sec after stimulus offset. Pupil response parameters to red and blue light were evaluated by paired t-test. Results: Except for the baseline pupil diameter (p = 0.148), there was a significant difference in all pupil response parameters to red and blue light (p = 0.001). With blue light, the relative amplitude was significantly greater and the time to maximal pupil constriction significantly longer compared to red light for all tested time points. Blue light evoked "sustained" pupil contraction, while red light rather induced "transient" contraction. Conclusions: Our examination protocol allowed us to unmask differences in pupil response to red and blue light in healthy subjects and to confirm involvement of the melanopsin retinal ganglion cells in the pupil light reflex, particularly with blue light. Chromatic pupillography appears to be a highly sensitive method for objective evaluation of the outer and inner retina function. |