Publication details

Účinnost fytoterapie v podpůrné léčbě diabetes mellitus typu 2 : II. Pískavice řecké seno (Trigonella foenum-graecum)

Title in English Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus : II. Fenugreek (Trigonella foenum-graecum)


Year of publication 2015
Type Article in Periodical
Magazine / Source Česká a slovenská farmacie
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords fenugreek; Trigonella foenum-graecum; diabetes mellitus type 2; biological activity
Description Fenugreek seeds are known for their characteristic smell of soup seasoning and as an ingredient of Indian curry. Traditionally the seeds are used as macerate for treatment of diabetes, cough, and flatulence, to increase breast milk secretion and for anti-inflammatory and aphrodisiac effects. The use is limited by unpleasant smell and bitter taste which can be modified by adding mint leaves to the macerate. Antidiabetic properties are attributed mainly to galactomannan, 4-hydroxyisoleucin (4-OH-Ile), diosgenin and trigonelline. These substances demonstrate direct antidiabetic properties in clinical studies by increasing insulin secretion (4-OH-Ile), decreasing insulin resistance and glucose resorption from GIT (galactomannan) and improvement in B-cells regeneration (trigonelline). Besides this main effect the herb improves blood lipid spectre (4-OH-Ile, diosgenin), have reno-protective (4-OH-Ile, trigonelline), neuroprotective (trigonelline) and antioxidant (diosgenin, trigonelline) effects. Antidiabetic efficacy of trigonelline is comparable to glibenclamide treatment and more effective than sitagliptine therapy. Given the large body of evidence and promising results in comparison with standard pharmacotherapy, fenugreek active substances have a potential to become a source of new antidiabetic medication.
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