Publication details

Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma: A treatment planning case report

Authors

KAZDA Tomáš POSPÍŠIL Petr VRZAL M. SEVELA O. PROCHAZKA T. JANČÁLEK Radim ŠLAMPA Pavel LAACK N.N.

Year of publication 2015
Type Article in Periodical
Magazine / Source CANCER RADIOTHERAPIE
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.canrad.2014.11.013
Field Oncology and hematology
Keywords Hippocampus; Astrocytoma; Neurocognition; Cranial irradiation
Description Timing of radiotherapy for low-grade gliomas is still controversial due to concerns of possible adverse late effects. Prevention of possible late cognitive sequelae by hippocampal avoidance has shown promise in phase II trials. A patient with progressive low-grade glioma with gradual dedifferentiation into anaplastic astrocytoma is presented along with description of radiotherapy planning process attempting to spare the hippocampus. To our knowledge, this is the first described case using volumetric modulated arc technique to spare hippocampus during transformed low-grade glioma radiotherapy. Using modern intensity-modulated radiotherapy systems it is possible to selectively spare hippocampus together with other standard organs at risk. For selected patients, an attempt to spare hippocampus can be considered as long as other dose characteristics are not significantly compromised compared to standard treatment plan created without any effort to avoid hippocampus.

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