Publication details

Engraftment of acute and chronic myeloid leukemia in NOD scid gamma mice

Authors

ČULEN Martin DVOŘÁKOVÁ D. SEMERÁD Lukáš ŠUSTKOVÁ Zuzana BOUCHNEROVÁ Jana PALACKOVÁ Martina MAYER Jiří RÁČIL Zdeněk

Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords xenograft; NSG mouse; AML; CML
Description The immunodeficient mouse represents an established animal model for leukemic transplantation studies. It is used both as a self-contained research tool for the study of leukemia genesis and progression, as well as for confirma¬tion of cell leukemogenic capability. The model as such has seen many modifications over the years, and while engraftment of primary acute and chronic myeloid leukemia samples is commonly feasible still not all samples can provide leukemic repopulation. This review specifically focuses on acute and chronic myeloid leukemia xe-nograft experiments using the current standard NOD.Cg-Prkdcxl° H2rg'm'w!'/SzJ mouse model and aims to provide a basic insight into the topic. It also discusses the various specifics relevant for conducting such experiments.
Related projects: