Publication details
Úloha cytokinů a chemokinů v indukci periferní neuropatické bolesti a jejich možné ovlivnění
| Title in English | A role of cytokines and chemokines in neuropathic pain induction and its possible modification |
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| Authors | |
| Year of publication | 2015 |
| Type | Article in Proceedings |
| Conference | Bolest a regenerace v medicíně |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | nerve injury; Wallerian degeneration; sterile inflammation |
| Description | Peripheral neuropathic pain is induced by traumatic, iatrogenic injury of the peripheral nerves or due to their affection by various diseases including HIV and diabetic neuropathy, post herpetic neuralgia or chemotherapy induced neuropathy. Dysbalance of somatosensory system is not caused only by direct injury of afferent axons but also, as displayed by results of experimental models, is induced by cellular and molecular changes after selective damage of motor innervation. For example, injury of the ventral roots of spinal nerves containing dominant motor axons arises pathophysiological mechanisms associated with induction of peripheral neuropathic pain. Neuropathic pain is resistant to classic analgetics, but also treatment by adjuvant analgetics (antidepressant and antiepileptic drugs) has many objectionable effects. A better knowledge of neuropathic pain pathophysiological mechanisms of neuropathic pain is challenge for preclinical research to try find new treatments. |
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