Publication details
Proces věkového úbytku mozkových funkcí u nekuřáků a kuřáků
| Title in English | Process of age-related decline of brain function among non-smokers and smokers |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Praktický lékař |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | smoking; memory; cognition; Alzheimer disease; mechanisms of pathogenesis |
| Description | Cardiovascular disease, chronic obstructive pulmonary disease and various forms of cancer are strongly associated with smoking. Now there is substantial epidemiologic evidence that smoking is also associated with impairment of brain functions (reduce of cognitive performances) as well as with some severe psychiatric morbidity, especially Alzheimer's disease and senile dementia. These symptoms and diseases are prevalent more often among smokers: their onset is in earlier age, even in middle age, and more rapid progression. Many clinical and experimental studies described the probable mechanisms of smoking influence: hypoxemia, free radicals, role of nicotinic acetylcholine receptors (nAChRs), neuroto-xicity for neurons and reduced thickness of brain cortex. Health consequences of neurotoxic influence of smoking are raising health and socio-economic problem, especially due to demographic ageing. Primary prevention of smoking and smoking cessation is the most effective methods for healthier elderly. |