Publication details

Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways

Authors

HAJNAL Matej ŠAFRÁNEK David DEMKO Martin PASTVA Samuel KREJČÍ Pavel BRIM Luboš

Year of publication 2016
Type Article in Proceedings
Conference Hybrid Systems Biology. HSB 2016
MU Faculty or unit

Faculty of Informatics

Citation
Doi http://dx.doi.org/10.1007/978-3-319-47151-8_4
Field Informatics
Keywords signalling pathways; systems biology; parameter synthesis; dynamical systems; parameter estimation
Description Signalling pathways provide a complex cellular information processing machinery that evaluates particular input stimuli and transfers them into the genome by means of regulation of specific genes expression. In this short paper, we provide a preliminary study targeting minimal models representing the topology of main signalling mechanisms. A special emphasis is given to distinguishing between monotonous (sustained) and non-monotonous (transient) time-course behaviour. A set of minimal parametrised ODE models is formulated and analysed in a workflow based on formal methods.
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