Project information
The national infrastructure C4SYS - Centre for Systems Biology
(C4SYS)
- Project Identification
- LM2015055
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Cooperating Organization
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Institute of Microbiology of the ASCR, v. v. i.
University of South Bohemia České Budějovice
Centrum výzkumu globální změny AV ČR, v. v. i.
The national infrastructure C4SYS - Centre for Systems Biology is a priority infrastructure project on the national roadmap, and currently in its preparatory phase, building on close collaboration between the Academy of Sciences (Institute of Microbiology, Prague, Institute of Nanobiology and Structural Biology, Nove Hrady, Global Change Research Center, Brno), the University of South Bohemia, and Masaryk University, Brno. It has the ambition to concentrate the knowledge potential in the field of systems biology in the Czech Republic and to connect the diverted systems biology research at the Academy of Sciences and various universities in the Czech Republic to the european infastructure (ISBE). C4SYS will enable Czech ad European laboratories to model, conduct experiments and proceed other activities, where they cannot be done locally, but which are required for their systems biology research. This virtual platform is providing the research community resources and services for the implementation of cutting-edge research and development internationally. This is an essential point because Systems Biology requires significantly more multidisciplinary facilities and international access than are typically present in any single institute. The infrastructure was initiated in 2009 as a divison of the former Institute of Systems Biology and Ecology of the Academy of Sciences of the Czech Republic, and became part of the Czech roadmap as a promising project in the 2010 update, and a high-priority project in the 2011 update. In 2014 the above mentioned institutions signed a memorandum of understanding, that finalizes the preparatory phase and initiates the construction phase that is planned for 2015-2017.
Publications
Total number of publications: 72
2021
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Engineering the protein dynamics of an ancestral luciferase
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The tetrameric structure of the novel haloalkane dehalogenase DpaA from Paraglaciecola agarilytica NO2
2020
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A Haloalkane Dehalogenase from Saccharomonospora viridis Strain DSM 43017, a Compost Bacterium with Unusual Catalytic Residues, Unique (S)-Enantiopreference, and High Thermostability
Applied and Environmental Microbiology, year: 2020, volume: 86, edition: 17, DOI
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Abrupt vegetation and environmental change since the MIS 2: A unique paleorecord from Slovakia (Central Europe)
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CaverDock: A Novel Method for the Fast Analysis of Ligand Transport
IEEE/ACM Transactions on Computational Biology and Bioinformatics, year: 2020, volume: 17, edition: 5, DOI
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Machine Learning in Enzyme Engineering
ACS Catalysis, year: 2020, volume: 10, edition: 2, DOI
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Newly identified DNA methyltransferases of Ixodes ricinus ticks
Ticks and Tick-borne Diseases, year: 2020, volume: 11, edition: 2, DOI
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Parallel parameter synthesis algorithm for hybrid CTL
Science of Computer Programming, year: 2020, volume: 185, edition: 102321, DOI
2019
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Accumulation of cyanobacterial oxadiazine nocuolin A is enhanced by temperature shift during cultivation and is promoted by bacterial co-habitants in the culture
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Barbaric Robustness Monitoring Revisited for STL* in Parasim
Computational Methods in Systems Biology (CMSB 2019), year: 2019