Publication details

Neuromuskulární symptomatologie jako první projev maligního onemocnění a původní evoluční význam změn chování, vyvolaných prozánětlivými cytokiny

Title in English Neuromuscular symtopatology as primary manifestation of a malignant neoplasm and a phylogenetic importance of behaviour changes induced by pro inflammatory cytokines
Authors

NEUWIRTHOVÁ Jana GÁL Břetislav SMILEK Pavel BINKOVÁ Hana URBÁNKOVÁ Pavla KOSTŘICA Rom

Year of publication 2016
Type Article in Periodical
Magazine / Source Onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords paraneoplastic symptom; sickness behaviour; pro-inflammatory cytokine; myalgia; insomnia; depression
Description Pro-inflammatory cytokines and hormonal changes in oncological diseases induce metabolic, neurological and psychic changes which could be presented as first symptoms of an occult malignant tumour. Moreover, the production of several types of auto-antibodies could make symptoms similar to autoimmune diseases. Specific behaviour changes due to pro-inflammatory signals from the periphery are characteristic for all mammals and have their own phylogenetic importance, which have been developed with wounded and sick animals in order to redistribute their energy resources to facilitate healing wounds and infections on the one hand, and to induce hyper-vigilance against a future predator attack on the other hand.

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