Publication details
Sequence-dependent separation of trinucleotides by ion-interaction reversed-phase liquid chromatography A structure-retention study assisted by soft-modelling and molecular dynamics
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Chromatography A |
| MU Faculty or unit | |
| Citation | |
| Web | supplementary data |
| Doi | http://dx.doi.org/10.1016/j.chroma.2016.09.060 |
| Field | Analytic chemistry |
| Keywords | Sequence-dependent separation; Ion-interaction reversed-phase liquid chromatography; Trinucleotides; Oligonucleotide sequence isomers; QSRR; Molecular dynamics |
| Attached files | |
| Description | Ultrashort oligonucleotides show consistent sequence-dependent separation behaviour, described via soft-modelling and molecular dynamics. Important factors determining this phenomenon were identified to be solvent accessible surface areas and electrostatic work of molecule transfer from vacuum into solvent, representing physico-chemical properties of the studied molecules. |
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