Publication details
Vztah likvorových hladin IL-6 ke změnám parciálního tlaku kyslíku v mozku a k rozvoji vazospazmů u pa cientů po subarachnoidálním krvácení z ruptury aneuryzmatu mozkové tepny
| Title in English | IL-6 Levels in the Cerebrospinal Fluid and their Association with Brain Oxygen Partial Pressure and Cerebral Vasospasm Development in Patients with Aneurysmal Subarachnoid Haemorrhage |
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| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | subarachnoid hemorrhage; inflammation; interleukin-6; brain tissue oxygen monitoring; Licox; transcranial dopplermetry; cerebral vasospasm |
| Description | Aim: The aim of this study was to evaluate whether levels of IL-6 in the cerebrospinal fluid are associated with parameters of transcranial dopplermetry or brain oxygen partial pressure (PbtO(2)) in patients with subarachnoid haemorrhage. Patients and methods: Patients with aneurysmal subarachnoid haemorrhage, who were unconscious during the fourth day after the onset of bleeding, were enrolled in the study. We explored associations between levels of IL-6 in the cerebrospinal fluid as measured on the fourth day after subarachnoid hemorrhage and transcranial dopplermetry parameters or brain oxygen partial pressure meassured one day later. Results: A total of 20 patients were enrolled into this study. There was a trend to higher levels of IL-6 in patients with cerebral vasospasm (med: 3,544; 25%/75% = perc: 2,106/6,907 vs. med: 10,080; 25%/75% perc: 2,540/13,958; p = 0.0946), however, no correlation between the levels of IL-6 and mean velocities in magistral vessels was observed. There was a tendency to higher levels of IL-6 related to PbtO2 lower than 20 mm Hg (med: 2,860; 25%/75% perc.: 940/8,580 vs. med: 6,937; 25%/75% perc: 3,811/14,524, p = 0.0587) and there was a significant correlation between the levels of IL-6 and PbtO(2) in our study group (rs = -0,626; p = 0.002). Conclusion: In this study group, there was a correlation between levels of IL-6 in the cerebrospinal fluid and subsequent PbtO(2) values at the beginning of the period representing the highest risk of delayed cerebral ischemia development. Based on these results we assume that IL-6 might be considered as a promising marker to predict risk of developing delayed cerebral ischemia. |