Publication details

Tyreotoxická periodická paralýza

Title in English Thyrotoxic periodic paralysis
Authors

DOLEŽEL Zdeněk NOVOTNÁ Dana SCHNEIDEROVÁ Helena PAPEŽ Jan JOUZA Martin

Year of publication 2016
Type Article in Periodical
Magazine / Source Pediatrie pro praxi
MU Faculty or unit

Faculty of Medicine

Citation
Field Paediatry
Keywords hypokalemia; hyperthyroidism; hypocalemic periodic paralysis
Description The majority of the body potassium is distributed in the intracellular space, and of which about 80% is in skeletal muscle. Movement of potassium in and out of skeletal muscle thus plays a pivotal role in extracellular potassium homeostasis. Thyrotoxic periodic paralysis (TPP) is a potentially lethal and rare complication of hyperthyroidism characterized by recurrent muscle weakness and hypokalemia. Acidobasic status is not impaired, however hypomagnesemia and hypophosphatemia may be also present. The diagnosis of TPP is confirmed on the basis of abnormal thyroid hormones. We describe a case of 17-year-old male who presented with acute onset weakness and hypokalemia. He was subsequently diagnosed with Graves’-Basedow disease.

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