Publication details
Crystal Structure of Human Enterovirus 71
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Science |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1126/science.1218713 |
| Field | Microbiology, virology |
| Keywords | PICORNAVIRUS; RECEPTOR; DISEASE |
| Description | Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket. |