Publication details

True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects

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Year of publication 2017
Type Article in Periodical
Magazine / Source Cytogenetic and Genome research
MU Faculty or unit

Faculty of Medicine

Field Genetics and molecular biology
Keywords Aneuploidy; Bivalents; Chromosome congression; Chromosome segregation; Meiosis; Nondisjunction; Oocyte
Description Chromosome segregation in mammalian oocytes is prone to errors causing aneuploidy with consequences such as precocious termination of development or severe developmental disorders. Aneuploidy also represents a serious problem in procedures utilizing mammalian gametes and early embryos in vitro. In our study, we focused on congression defects during meiosis I and observed whole nondisjoined bivalents in meiosis II as a direct consequence, together with a substantially delayed first polar body extrusion. We also show that the congression defects are accompanied by less stable attachments of the kinetochores. Our results describe a process by which congression defects directly contribute to aneuploidy. (C) 2017 S. Karger AG, Basel
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