Publication details
Retinoidy v dermatologii
| Title in English | Retinoids in Dermatology |
|---|---|
| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Česká dermatovenerologie |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | retinoids; systemic therapy; practical use and perspective in dermatology |
| Description | The authors discuss the history of the development and classification of retinoids, their pharmacodynamic properties, including the biological potential for the treatment. The overview discusses the pharmacological and clinical characteristics of topical and systemic retinoids, their availability and current conditions of reimbursement in the Czech Republic. The main part is the use of retinoids in practice, more in detail the use of three systemic retinoids - acitretin, bexarotene and isotretinoin. The tables show the standard indications as well as the less common possibilities of their use, contraindica-tions, dosing and current recommendations for clinical and laboratory examinations before and during treatment and follow-up. Detailed šidě effects and measures for their prevention, alleviation and early recognition are discussed. The advanlages of retinoids such as the absence of immunosuppression, the possibility of combination therapy, the minimal drug interactions, and a generally good safety profile that outweight the potential risks that allow their use for long-term maintenance therapy, are also emphasized. |