Publication details

INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS

Authors

VIDO Marek JAROŠOVÁ Petra TÁBORSKÝ Petr PEŠ Ondřej

Year of publication 2018
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description G-quadruplex DNA (G4) has been known to be involved in many physiological processes in the cell e.g., in the promoter regions of oncogenes or in the human telomeric region. Because of their supposed role in cancer, G4 are often studied as targets for anti-cancer drugs. Natural and/or synthetic compounds, which are able to selectively bind these structures, have been intensively tested by means of molecular spectrometry, circular dichroism, equilibrium dialysis, and mass spectrometry. Compounds may interact with G4 by several mechanisms with various affinities. An approach to study a great number of potential effective compounds relies on combination of methods when relatively fast; however, imprecise mass spectrometry was used to preselect compounds, which were then subjected to more precise techniques studying G4 in a solution.
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