Publication details

The optimal bowel preparation intervals before colonoscopy: A randomized study comparing polyethylene glycol and low-volume solutions

Authors

KOJECKY Vladimir MATOUS Jan KEIL Radan DASTYCH Milan ZADOROVA Zdena VARGA Michal KROUPA Radek DOLINA Jiří MISUREC Miroslav HEP Aleš GRIVA Martin

Year of publication 2018
Type Article in Periodical
Magazine / Source DIGESTIVE AND LIVER DISEASE
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.dld.2017.10.010
Keywords Ascorbic acid; Bowel preparation; Colonoscopy; Polyethylene glycol; Sodium picosulfate
Description Background & aims: The optimal duration of bowel preparation has only been assessed for polyethylene glycol (PEG). The aim of the study was to determine the intervals for achieving a satisfactory quality/tolerability of the preparation using PEG/ascorbic acid (PEGA) and sodium picosulphate/magnesium citrate (SPMC), and to compare them with 4L of PEG. Methods: A randomized, endoscopist-blinded, multicentre study. The 612 outpatients referred to a colonoscopy, were prepared using PEG, SPMC, PEGA. The quality, tolerability, duration of the preparation, and the interval from the end of the preparation to the colonoscopy was assessed. Results: Optimum duration of the preparation was similar for both PEG and SPMC (>= 7.3 vs. >= 8.8 h, overall >= 8.4 h). Optimum interval to the colonoscopy was <= 11.8 h and did not differ between preparations (PEG, PEGA <= 11.8, SPMC <= 13.3 h). These times were the only predictors for a satisfactory preparation. The tolerability depends on the product type (SPMC) only. Timing of the preparation or the other factors had no impact on tolerability. Conclusion: The optimum intervals for bowel preparation are identical for all preparations. Satisfactory preparation is achived at the preparation length >= 8.4 h and the time to colonoscopy <= 11.8 h.

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