Publication details

Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition

Authors

GURÍN Dominik SLÁVIK Marek HERMANOVÁ Markéta SHATOKHINA Tetiana ŠÁNA Jiří KAZDA Tomáš SELINGEROVÁ Iveta AHMAD Parwez SMILEK Pavel HORÁKOVÁ Zuzana HENDRYCH Michal ŠLAMPA Pavel SLABÝ Ondřej

Year of publication 2018
Type Article in Periodical
Magazine / Source JOURNAL OF ORAL PATHOLOGY & MEDICINE
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1111/jop.12772
Keywords CD44; combined immunoprofiles; EGFR; OPSCC; p16
Description ObjectivesTo examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer (AJCC) 8th edition staging system in comparison with 7th edition was analyzed. MethodsThe study included 77 OPSCC patients treated by definitive intensity-modulated radiotherapy (IMRT). Clinical staging was assessed according to the AJCC, both 7th and 8th edition. Immunohistochemical (IHC) analysis of CD44 and EGFR was performed on primary biopsy tumor tissues. To evaluate the HPV status, IHC detection of p16 was employed. ResultsThe AJCC 8th edition staging system revealed correlations between overall survival (OS), progression-free survival (PFS), locoregional control (LRC), and clinical stage. EGFR and CD44 positivity (+) and p16 negativity (-) were associated with clinical stage IV of the disease. CD44+ and EGFR+ OPSCC displayed worse OS and LRC, and these cases also showed the worst 3-year OS and LRC. Combined analysis of protein expressions identified an association between p16- and EGFR+, p16- and CD44+, EGFR+, and CD44+. Combined immunoprofiles CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ were associated with worst OS and LRC. ConclusionsCombined immunoprofiles of p16, EGFR, and CD44 might provide valuable prognostic and predictive information for the individual OPSCC patients, especially in terms of response to IMRT and prediction of treatment outcomes. Application of the AJCC 8th edition staging for HPV+ OPSCC proved to improve hazard discrimination and prognostication of OPSCC.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info