Publication details

Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

Authors

SLANINA Tomáš ŠEBEJ Peter

Year of publication 2018
Type Article in Periodical
Magazine / Source PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract
Doi http://dx.doi.org/10.1039/c8pp00096d
Keywords PHOTOREMOVABLE PROTECTING GROUPS; METAL-CARBONYL-COMPLEXES; PROTEIN-KINASE PATHWAY; LIVING CELLS; NITRIC-OXIDE; AQUEOUS-SOLUTION; NIR LIGHT; IN-VIVO; STRUCTURAL-CHARACTERIZATION; XANTHENE-9-CARBOXYLIC ACID
Description To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.
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