Publication details

Capillary Electrophoretic Method with Fluorescence Detection as a Promising Tool for Screening of Beta-Secretase Inhibitors

Authors

ŘEMÍNEK Roman SCHEJBAL Jan GLATZ Zdeněk

Year of publication 2018
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Alzheimer’s disease (AD) represents the most common cause of dementia. According to amyloid cascade hypothesis, pathogenesis of the disease could be slowed down or even stopped by inhibition of beta-secretase (BACE). Capillary electrophoretic (CE) methods are regarded as a promising tool for enzyme assays. A CE method with fluorescence detection for screening of potential BACE inhibitors was therefore introduced.
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