Publication details

Markers of Atherosclerosis. Part 1, Serological Markers

Authors

TIBAUT Miha CAPRNDA Martin KUBATKA Peter SINKOVIC Andreja VALENTOVA Vanda FILIPOVA Slavomira GAZDIKOVA Katarina GASPAR Ludovit MOZOS Ioana EGOM Emmanuel E. RODRIGO Luis KRUŽLIAK Peter PETROVIC Daniel

Year of publication 2019
Type Article in Periodical
Magazine / Source HEART LUNG AND CIRCULATION
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1016/j.hlc.2018.06.1057
Doi http://dx.doi.org/10.1016/j.hlc.2018.06.1057
Keywords Biomarkers; Atherosderosis; High sensitivity C-reactive protein
Description Atherosclerosis is a major contributor to morbidity and mortality worldwide. With therapeutic consequences in mind, several risk scores are being used to differentiate individuals with low, intermediate or high cardiovascular (CV) event risk. The most appropriate management of intermediate risk individuals is still not known, therefore, novel biomarkers are being sought to help re-stratify them as low or high risk. This narrative review is presented in two parts. Here, in Part 1, we summarise current knowledge on serum (serological) biomarkers of atherosclerosis. Among novel biomarkers, high sensitivity C-reactive protein (hsCRP) has emerged as the most promising in chronic situations, others need further clinical studies. However, it seems that a combination of serum biomarkers offers more to risk stratification than either biomarker alone. In Part 2, we address genetic and imaging markers of atherosclerosis, as well as other developments relevant to risk prediction.
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