Publication details

Offspring of women with gestational diabetes – a prospective study with 3 year follow-up



Year of publication 2019
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Description Introduction Gestational diabetes mellitus (GDM) represents a risk factor for mother and child in both short-term (peripartal morbidity) and long-term horizon (diabetes postpartum and foetal programming). Numerous studies focused on birth and peripartal complications in the offspring of women with GDM, however fewer studies prospectively followed these children. Higher risk of obesity, hypertension or diabetes is supposed similarly to offspring of women with T2DM. No such a study was performed in Czech population. Material and methods A total of 592 women (of those 496 women had GDM and 96 were healthy women) were addressed with a request to fill an electronic questionnaire with aim to find out basic parameters of their children younger than 3 years (from health documentation of the child – weight, height, head circumference, psychomotor development, morbidity, the need for drugs/hospitalization, the need for monitoring by a specialist, the state of vaccination and breast-feeding duration). 55 women filled the questionnaire (48 with GDM and 7 with physiologic pregnancy). Postpartum impaired glucose tolerance (IGT) remained in 4 women with GDM. We compared offspring of women with and without GDM and also subgroups of offspring of women with GDM (those with and without IGT postpartum). Following parameters were compared in mothers: age, BMI, weight increment during pregnancy, diabetes (DM) in the family, smoking, parity, and overweight/obesity. Results Healthy mothers had less commonly DM in family case history compared to women with GDM and they were more commonly primiparas (P=0,037, resp. P=048, chi-square test). Comparison of GDM subgroups showed significantly more common smoking in the anamnesis of those with IGT postpartum (P=0,003, chi-square test). We did not find statistically significant differences in selected parameters between offspring of women with and without GDM or between offspring of women with GDM with and without IGT postpartum although certain trends in results can be seen – offspring of women with GDM are less commonly breast-fed, less commonly receive vaccination according to the recommended scheme and more commonly need medical treatment by a specialist (allergologist and orthopedist) compared to offspring of healthy mothers. Conclusion Compliance of respondents was very small (approximately 10 % of all addressed filled the questionnaire which corresponds to worldwide trend), therefore we are not able to provide reliable statistically significant results. Our results suggest certain differences between offspring of women with and without GDM, however more participants needs to be included.
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